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TOPIC: IGF-1 LR3 and IGF-1 DES Peptides Thoughts

IGF-1 LR3 and IGF-1 DES Peptides Thoughts 1 year 3 months ago #14008

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Dear ladies and gents,

Gonna be sharing my thoughts on IGF-1 LR3/DES.

Many websites selling IGF-1 LR3/DES peptides are referring to SIGMA Aldrich/Repligen websites :
"LONG® R3 IGF-I is a recombinant analog of human insulin-like growth factor-I (IGF-I) that has been specifically engineered for the enhancement of cell culture performance. It is more biologically potent in vitro than either insulin or native IGF-I and has been shown to significantly increase recombinant protein production. It is ideal for both research and large-scale culture systems utilizing serum-free or low-level serum applications"

Repligen :

"LONG®R3 IGF-I is a critically important mitogenic growth factor often used in mammalian cell culture to increase yield significantly."

"More biologically potent in vitro than either insulin or native IGF-I"

In vitro! This is what SOME igf-1 Lr3/Des PEPTIDE vendors forget to mention... IGF-1 LR3 is superior to IGF-1 when it comes to IN VITRO RESEARCH, we can simply call it a better reagent for certain laboratory applications. It may be performing better in a "tube" does it work the same IN VIVO???
Have you seen a single study done on HUMANS with IGF-1 LR3/DES? Try googling it and feel free to post a link to the study here.

Sold to athletes as a more potent version of Recombinant Human IGF-1 = The Perfect Snake oil.
Why? It won't raise your IGF-1 levels, it can't be detected in your blood sample. Not a single blood test done by anyone using IGF-1 LR3 proven the opposite. The molecule is different, the lab equipment used to detect IGF-1 won't detect IGF-1 LR3/DES. So the peptide you get can be anything.

If IGF-1 LR3/DES works, what's the mechanism of action in human body?
Recombinant Human IGF-1 binds to IGF-1 and Insulin receptors. If the molecule is different from the RH IGF-1, will IGF-1 LR3/DES bind to the same receptors? FYI : IGF-1 LR3 = 83 Amino acids, IGF-1 = 70 AA. Can 2 different keys gain access the same lock?

Antibodies? Let's not forget that IGF-1 LR3 peptide doesn't resemble any protein/molecule produced by our body. We all remember the rumor that some "Chinese" factories were selling 192 AA instead of 191 AA (HGH) which the community believe led to the red welts. It's a common sense, you don't want to inject something that our body can reject. IGF-1 LR3 (83 AA) is that 192 AA, if you don't get the red welts, it doesn't mean your body doesn't waste it's resources on producing antibodies and fighting the "Intruder Growth Factor LR3". Weakened immune system is one of the consequences of these experiments. Yet not a single research can confirm the statement is wrong.

To sum it up :
  • The mechanism of action of IGF-1 LR3/DES peptides in human body : UNKNOWN.
  • Detectable in blood? No.
  • Effectiveness: Yet to be proven.
  • Safety: Yet to be studied.
  • Antibodies?: Yet to be studied.
  • Created for In vitro research and marketed as such by Repligen/Sigma Aldrich.
    No Human/Pharma Grade version of the substance exists.
Last Edit: 1 year 3 months ago by Administrator.
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IGF-1 LR3 and IGF-1 DES Peptides Thoughts 1 year 2 months ago #14079

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As a proof of false representation that's practiced by majority peptides companies, posting this print screen.

h5331adc.jpg


They refer to research gate, many won't see that the study is done on pure IGF-1 and not a modified version of IGF-1.

www.researchgate.net/figure/In-genetical...e-are_fig3_224811043
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IGF-1 LR3 and IGF-1 DES Peptides Thoughts 1 year 2 months ago #14095

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Gents, Happy Friday. =)

Came across this post this morning :
"The Inclelex is indicated for certain types of Dwarfism, for athletic/anti-aging purposes the IGF1-lr3 is more suited, and indeed the FDA approved IGF1-lr3 for anti-aging purposes. The dosages of different peptide hormones (such as GH and IGF) are indicated per body weight. The IGF1-lr3 is much more cost effective in this regard, and this is certainly something to consider when we refer to patients (that unlike Dwarf childs) may weight well over 200lbs"

I can't post on the forum where I found this msg yet, but I'll will soon =) So as a part of me spreading awareness among athletes gonna comment it on our forum.

1) "for athletic/anti-aging purposes the IGF1-lr3 is more suited"
No. IGF-1 LR3/Des are for the lab use. It's a never researched "for human use" chemicals, with 100% UNKNOWN pharmacokinetics which means nobody knows how this substance work if injected into human body and nobody knows an outcome of a long term use of these chemicals. It's effectiveness has never been proven not to mention the safety.

2) "indeed the FDA approved IGF1-lr3 for anti-aging purpose"
There's no such thing as FDA approved IGF-1 lr3/Des. Anti-aging purposes? YES, you may not get old if you use them. Live fast die young.

3) Treating Dwarfism and bodybuilding are two different things. Do bodybuilders want to make their bones grow? No, but children with Dwarfism do. This explains difference in dosages.

RS
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IGF-1 LR3 and IGF-1 DES Peptides Thoughts 10 months 1 week ago #14498

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Keep receiving email from people who ask about the difference between LR3/DES and Insubolic.

Insubolic is Recombinant HUMAN IGF-1, LR3/DES are reagents for lab use with no clinical or even scientific data proving their safety or efficacy as PED agent.

IGF-1 is bound to six IGF binding proteins, with > 80% bound as a complex with IGFBP-3 and an acid-labile subunit.

Most studies concerning the effects of IGF-1 derivatives have been carried out in animal models, with little to no data available for humans.

IGF-I variants which bind poorly to IGF-binding proteins show more potent and prolonged hypoglycaemic action than native IGF-I in pigs and marmoset monkeys

(DES - LR3)

www.researchgate.net/public...han_native...and_marmoset_monkeys
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IGF-1 LR3 and IGF-1 DES Peptides Thoughts 10 months 1 week ago #14499

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The Tim Ferriss Show - #143: The World's Most Famous Performance-Enhancement Chemist on Stitcher

www.stitcher.com/show/the-tim-ferriss-sh...ent-chemist-46641568

Patrick Arnold: I think the biggest waste of money is this IGF LR3.

Tim Ferriss: Mm-hmm. Can you explain what that is?

Patrick Arnold: Well, IGF – Tim Ferriss: It's [inaudible] growth factor, but LR3, I've actually never heard of. I've never heard those three letters.

Patrick Arnold: Okay. Well, I'll make it brief. IGF1 is the most – it's a big anabolic hormone in your body. When you take growth hormone, pretty much all the anabolic activity that's growth hormone manifests itself through is IGF1, that's made in the liver. You take growth hormone, there's growth hormone receptors in the liver. They get turned on. Your liver pumps out IGF1. IGF1 goes out. That's what makes your bones grow, your ligaments grow and whatnot. If you're young enough, maybe your muscles too. Now back in the '90s, there was no IGF1, regular IGF1 available. What was available was this derivative, or this analog of IGF1 that had an amino acid taken off to allow it to not bind to what are known as IGF1 binding proteins. The reason why they did that was because it was meant for petri dish, in vitro studies, and they wanted the IGF1 to be free to do exactly what it had to do, and not worry about binding to stuff, and then it would throw the experiment off or whatever. So this stuff was never meant for humans. But it was available, so people were like, "Oh, it's the best IGF1 because it doesn't bind to binding proteins," and people were taking it. The whole thing is the fact that it doesn't bind to these binding proteins, means that when you shoot it in your body, your body breaks it down almost immediately because the way your body uses IGF1, it actually has to bind to something called IGF1 binding protein 3. Which titrates it, extends its half-life, delivers it to the tissues at the right time and whatnot. So people are still stuck under this illusion that this in vitro version of IGF1, which is cheap, still works. By now, people are not really talking about it because enough people have tried it and seeing it doesn't do anything. But it's still in people's arsenal for some reason.

Tim Ferriss: The IGF LR3?

Patrick Arnold: IGF – yeah, LR3. Yup.

P.S. There's Recombinant Human IGF-1 (bioidentical to Human IGF-1) and LR3/DES. Lr3/DES is not for human use (no clinical data on it's safety nor any scientific data on how it may boost your physical performance).

tim.blog/wp-content/uploads/2018/08/143-patrick-arnold.pdf
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IGF-1 LR3 and IGF-1 DES Peptides Thoughts 10 months 3 days ago #14542

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There needs to be proper protein folding in order for the peptide to become biologically available. E.coli is generally used for this purpose. Putting a bunch of amino acids in the same sequence doesn't make it usable.
One counter point is different hormones or peptides can unlock the same receptor even if they are overall different due to only a small section of the peptide attaching to the receptor.
J
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